The urinary elimination of nicotinamide methochloride by man.
نویسندگان
چکیده
The development of a method for the estimnation of nicotinamide methochloride in urine by Coulson, Ellinger & Holden (1944) provided, a means of studying its quantitative elimination in human urine under a variety of conditions. A preliminary method (Coulson, Ellinger, Glock & Platt, 1942) which gave only cbmparative but not quantitative results had been used before the chemical nature of the pigments involved was elucidated by Huff & Perlzweig (1943), Ellinger & Coulson (1943) and Coulson & Ellinger (1943). This paper is eoncerned with the elimination of nicotinamide methochloride by a number of subjects tinder normal conditions and under the influence of some extrinsic factors. The effect of the intake of nicotinamide and several related compounds on the elimination of the methylated derivative was studied, and an attempt was made to determine the state of saturation in man with respect to nicotinamide.
منابع مشابه
The fate of nicotinamide methochloride and the effect of liver poisons on its elimination rate in the rat.
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 38 3 شماره
صفحات -
تاریخ انتشار 1944